DBS Think Tank IX was held on August 25–27, 2021 in Orlando FL with US based participants largely in person and overseas participants joining by video conferencing technology. The DBS Think Tank was founded in 2012 and provides an open platform where clinicians, engineers and researchers can freely discuss current and emerging deep brain stimulation technologies as well as the logistical and ethical issues facing the field. The consensus among the DBS Think Tank IX speakers was that DBS expanded in (...) its scope and has been applied to multiple brain disorders in an effort to modulate neural circuitry. After collectively sharing our experiences, it was estimated that globally more than 230,000 DBS devices have been implanted for neurological and neuropsychiatric disorders. As such, this year’s meeting was focused on advances in the following areas: neuromodulation in Europe, Asia and Australia; cutting-edge technologies, neuroethics, interventional psychiatry, adaptive DBS, neuromodulation for pain, network neuromodulation for epilepsy and neuromodulation for traumatic brain injury. (shrink)

We estimate that 208,000 deep brain stimulation (DBS) devices have been implanted to address neurological and neuropsychiatric disorders worldwide. DBS Think Tank presenters pooled data and determined that DBS expanded in its scope and has been applied to multiple brain disorders in an effort to modulate neural circuitry. The DBS Think Tank was founded in 2012 providing a space where clinicians, engineers, researchers from industry and academia discuss current and emerging DBS technologies and logistical and ethical issues facing the field. (...) The emphasis is on cutting edge research and collaboration aimed to advance the DBS field. The Eighth Annual DBS Think Tank was held virtually on September 1 and 2, 2020 (Zoom Video Communications) due to restrictions related to the COVID-19 pandemic. The meeting focused on advances in: (1) optogenetics as a tool for comprehending neurobiology of diseases and on optogenetically-inspired DBS, (2) cutting edge of emerging DBS technologies, (3) ethical issues affecting DBS research and access to care, (4) neuromodulatory approaches for depression, (5) advancing novel hardware, software and imaging methodologies, (6) use of neurophysiological signals in adaptive neurostimulation, and (7) use of more advanced technologies to improve DBS clinical outcomes. There were 178 attendees who participated in a DBS Think Tank survey, which revealed the expansion of DBS into several indications such as obesity, post-traumatic stress disorder, addiction and Alzheimer’s disease. This proceedings summarizes the advances discussed at the Eighth Annual DBS Think Tank. (shrink)

Im Zuge der fortschreitenden Globalisierung der Wirtschaft kooperieren Wirtschaftsakteure immer häufiger mit Partnern in anderen Teilen der Welt, die anderen kulturellen Rahmenbedingungen verpflichtet sind. Dabei treten oft Handlungs- und Normkonflikte auf. Das vorliegende Buch behandelt diese transkulturellen Wertekonflikte aus unterschiedlichen philosophischen und wirtschaftsethischen Perspektiven: Grundsatzfragen der Transkulturalität, wie die Gefahr des Verlusts des Fremden werden ebenso behandelt wie der mögliche Umgang mit transkulturellen Wertekonflikten oder die Frage nach einer ökonomischen Moral. Ein besonderer Schwerpunkt wird auf den Aspekt des Kulturwandels und (...) des Kulturrelativismus gelegt. Konkrete Beispiele und empirische Studienergebnisse, etwa zu den deutsch-russischen Wirtschaftsbeziehungen, der Wirtschaft in Südkorea oder den Wertedifferenzen in einem multinationalen Unternehmen machen die Beiträge auch für die wirtschaftsethische Praxis relevant. TOC:K. Röttgers: Der Verlust des Fremden.- C. Hubig: Transkulturelle Wertkonflikte im Spannungsfeld zwischen abstrakter Harmonisierung und Anwendungsdissensen.- H. Busche: Was sind transkulturelle Wertekonflikte? Und inwieweit sind sie lösbar?- P. Koslowski: Wirtschaft als Kultur.- B.P. Priddat: Modernisierung einer Relation: Ökonomie/Moral.- J. Wieland: Die Governance kultureller Diversifität. Resultate einer empirischen Studie über die Bedeutung von Werten in deutsch-russischen Unternehmensbeziehungen.- J. Meran: In the long run we all become Americans. Anmerkungen zum Kulturwandel der Multis.- R. Manstetten/M.-Y. Lee: Zugehörigkeit, Verschuldung und Vermittlung. Zur Ordnung wirtschaftlicher Beziehungen in Südkorea.- M. Kettner: Kultur, Kulturrelativität, Kulturrelativismus. (shrink)

Answering some of the main questions from [L. Motto Ros, The descriptive set-theoretical complexity of the embeddability relation on models of large size, Ann. Pure Appl. Logic164(12) (2013) 1454–1492], we show that whenever κ is a cardinal satisfying κ<κ=κ>ω, then the embeddability relation between κ-sized structures is strongly invariantly universal, and hence complete for (κ-)analytic quasi-orders. We also prove that in the above result we can further restrict our attention to various natural classes of structures, including (generalized) trees, graphs, or (...) groups. This fully generalizes to the uncountable case the main results of [A. Louveau and C. Rosendal, Complete analytic equivalence relations, Trans. Amer. Math. Soc.357(12) (2005) 4839–4866; S.-D. Friedman and L. Motto Ros, Analytic equivalence relations and bi-embeddability, J. Symbolic Logic76(1) (2011) 243–266; J. Williams, Universal countable Borel quasi-orders, J. Symbolic Logic79(3) (2014) 928–954; F. Calderoni and L. Motto Ros, Universality of group embeddability, Proc. Amer. Math. Soc.146 (2018) 1765–1780]. (shrink)

La philosophie contemporaine et la phénoménologie du corps, en visant à rendre le corps plus multiple, plus habité par l'altérité y compris technique (J. Derrida, J.-L. Nancy), ont fait évoluer profondément le problème du lien entre "l'âme" et le corps ; et cela au-delà des contours de la problématique marquée par les recherches cognitives du XXe siècle, qui ont pourtant donné une accélération remarquable à l'étude des rapports entre le cerveau et la machine corporelle. Ces perspectives ont introduit dans le (...) cadre de l'ancien débat, d'origine cartésienne, des variantes liées surtout à l'art, l'écriture et la pensée environnementale. L'Orient et l'Occident se retrouvent ainsi confrontés à un corps aux multiples "décors", qui le spécifient, l'entourent, l'enrichissent, etc. Le Mind Body Problem d'ordre simplement épistémologique, suivant la tradition jusqu'à la seconde moitié du siècle dernier, s'est changé en problème culturel, cognitif, écologique qui récupère de façon critique la notion générale de "vie", de "contexte phénoménologique de vie", d'existence également. Ce volume, issu d'un Colloque organisé par le Collège International de Philosophie, a voulu reconsidérer les tenants et aboutissants de ce changement, pour le développement d'une perspective de philosophie du corps impliquant une multitude d'intersections trans-et multidisciplinaires et trans- et multiculturelles : entre esthétique, arts du spectacle, phénoménologie, écologie, histoire de l'art et de la pensée de l'art, pensée orientale, nouvelles sciences cognitives, Cultural Studies. (shrink)

Les quinze sections de cet ouvrage proposent un parcours de réflexion à partir du démantèlement sadien de la normativité et de la déconstruction kierkegaardienne de la vie "bonne", qui engage des auteurs tels qu'Adorno, Arendt, Otto Gross, Agnes Heller, Kalivoda, Lacan, Cavell, Nussbaum, parmi d'autres, dans une analyse inusitée de la subjectivité révolutionnaire et des individualités révoltées. Ces critiques de l'aliénation comme "métaphysique de l'essence humaine" relancent, d'après l'autrice, la continuité artistique et l'aspiration politique du romantisme révolutionnaire, réinstallant ainsi la (...) dialectique permanente du libertinisme et du romanticisme au coeur même de l'échafaudage communiste comme scène réelle, symbolique et imaginaire de l'émancipation humaine."--Page 4 of cover. (shrink)

Radical Orthodoxy (RO) accepts the post-structuralist critiques of autonomous human agency while liberation theologians embrace Enlightenment ideals ofsubjectivity and the secular political space where agency is exercised. RO theologians think that by accepting these premises, liberation theology fails to resist violence and nihilism that are the inevitable fruit of secular autonomy. I want to formulate a liberationist response to these objections. Liberationists do not see human and divine agency as fundamentally opposed, but rather the deepest strivings of the human spirit (...) for justice are on the same trajectory as the Kingdom of God. Human and divine agency are tied together through the notion of a utopia whereby these strivings for justice are expressed in a finite and historical way. This emancipative use of reason in the construction of a utopia provides a means for divine and human agency to interact without destroying the human autonomy of the secular sphere. (shrink)

Radical Orthodoxy (RO) accepts the post-structuralist critiques of autonomous human agency while liberation theologians embrace Enlightenment ideals ofsubjectivity and the secular political space where agency is exercised. RO theologians think that by accepting these premises, liberation theology fails to resist violence and nihilism that are the inevitable fruit of secular autonomy. I want to formulate a liberationist response to these objections. Liberationists do not see human and divine agency as fundamentally opposed, but rather the deepest strivings of the human spirit (...) for justice are on the same trajectory as the Kingdom of God. Human and divine agency are tied together through the notion of a utopia whereby these strivings for justice are expressed in a finite and historical way. This emancipative use of reason in the construction of a utopia provides a means for divine and human agency to interact without destroying the human autonomy of the secular sphere. (shrink)

Rho GTPases are critically important and are centrally positioned regulators of the actomyosin cytoskeleton. By influencing the organization and architecture of the cytoskeleton, Rho proteins play prominent roles in many cellular processes including adhesion, migration, intra‐cellular transportation, and proliferation. The most important method of Rho GTPase regulation is via the GTPase cycle; however, post‐translational modifications (PTMs) also play critical roles in Rho protein regulation. Relative to other PTMs such as lipidation or phosphorylation that have been extensively characterized, protein oxidation is (...) a regulatory PTM that has been poorly studied. Protein oxidation primarily occurs from the reaction of reactive oxygen species (ROS), such as hydrogen peroxide (H2O2), with amino acid side chain thiols on cysteine (Cys) and methionine (Met) residues. The versatile redox modifications of cysteine residues exemplify their integral role in cell signalling processes. Here we review prominent members of the Rho GTPase family and discuss how lipidation, phosphorylation, and oxidation on conserved cysteine residues affects their regulation and function. (shrink)

Husserl rejects the contrast between human life as an irrational factum and reason as an objectifying force that is hostile to life. Hence he moves away from the incompatibility between philosophy as science and philosophy of life. This paper has two purposes. First, it attempts to analyze the sequence of living horizons of reason, i.e., to lay out a progressive bringing-into-play that begins in a primal history linked to instinct, goes through history proper with its manners of practical reason, and (...) reaches its culmination in a second historicity with a teleological development. In his last dated manuscript, Husserl speaks of “the upright, fair reason of the natural, sound human understanding” that plays a role before “the scientific, philosophical reason”. Secondly, against this background, phenomenology of reason is considered as a view that is grounded in passive fulfillments, traces theory back to life, and emphasizes the interpenetration of the various manifestations of reason. It is argued that the relationship between intention and fulfillment pervades the movement from latent to manifest reason, renders possible different modes of rational legitimation, and shows distinctive traits in each mode. With regard to the vitality of Husserlian reason, a brief epilogue for the Spanish speaking world deals with some of J. Ortega y Gasset’s views on the issue.Husserl rechaza la contraposición entre la vida humana como un factum irracional y la razón como una fuerza objetivante hostil a la vida. Por eso se aparta de la incompatibilidad entre la filosofía como ciencia y la filosofía de la vida. Este trabajo tiene dos propósitos. Prime-ro, intenta analizar la secuencia de horizontes vitales de la razón, es decir, desplegar una progresiva puesta-en-juego que se inicia en la protohistoria ligada al instinto, pasa a través de la historia en sentido propio con sus modalida-des de razón práctica, y culmina en una segun-da historicidad con un desarrollo teleológico. En su último manuscrito fechado, Husserl habla de “la proba y honrosa razón del entendimiento humano natural” que desempeña un papel con anterioridad a “la razón científica, la filosófica”. En segundo lugar, frente a este trasfondo, se examina la fenomenología de la razón como una visión que se funda en cum-plimientos pasivos, refiere la teoría a la vida, y pone énfasis en la compenetración de las varia-das manifestaciones de la razón. Se sostiene que la relación entre intención y cumplimiento atraviesa el movimiento desde la razón latente a la razón patente, hace posible diversos modos de legitimación racional, y muestra rasgos distintivos en cada uno de los modos. Respecto de la vitalidad de la razón husserliana, un breve epílogo para hispanoparlantes considera algu-nos puntos de vista de J. Ortega y Gasset sobre la cuestión. (shrink)

Introduction of O2 to Earth's early biosphere stimulated remarkable evolutionary adaptations, and a wide range of electron acceptors allowed diverse, energy-yielding metabolic pathways. Enzymatic reduction of O2 yielded a several-fold increase in energy production, enabling evolution of multi-cellular animal life. However, utilization of O2 also presented major challenges as O2 and many of its derived reactive oxygen species are highly toxic, possibly impeding multicellular evolution after the Great Oxidation Event. Remarkably, ROS, and especially hydrogen peroxide, seem to play a major (...) part in early diversification and further development of cellular respiration and other oxygenic pathways, thus becoming an intricate part of evolution of complex life. Hence, although harnessing of chemical and thermo-dynamic properties of O2 for aerobic metabolism is generally considered to be an evolutionary milestone, the ability to use ROS for cell signaling and regulation may have been the first true breakthrough in development of complex life. The importance of Earth's oxygen cycle and reactive oxygen species produced on the evolution of complex life. The ability to detoxify oxygen species is not a trait that emerged as a response to increased O2 levels but rather crucial adaptation to the early Earth's weakly oxic microenvironments. (shrink)

Un humaniste indépendant: W.C. Brownell et le rôle de la critique.--La doctrine de l'humanisme: l'œuvre d'Irving Babbit.--L'humanisme et la religion: lœuvre de Paul Elmer More.--Conclusion: L'utilisation de l'humanisme--Traductions: "Emerson", par W.C. Brownell. "L'humanisme et l'imagination", par Irving Babbitt. "La littérature victorienne et la philosophie du changement", par Paul Elmer More.

Programmed cell death (PCD) is a process aimed at the removal of redundant, misplaced, or damaged cells and it is essential to the development and maintenance of multicellular organisms. In contrast to the relatively well‐described cell death pathway in animals, often referred to as apoptosis, mechanisms and regulation of plant PCD are still ill‐defined. Several morphological and biochemical similarities between apoptosis and plant PCD have been described, including DNA laddering, caspase‐like proteolytic activity, and cytochrome c release from mitochondria. Reactive oxygen (...) species (ROS) have emerged as important signals in the activation of plant PCD. In addition, several plant hormones may exert their respective effects on plant PCD through the regulation of ROS accumulation. The possible plant PCD regulators discussed in this review are integrated in a model that combines plant‐specific regulators with mechanisms functionally conserved between animals and plants. BioEssays 25:47–57, 2003. © 2002 Wiley Periodicals, Inc. (shrink)

Einleitung von H. Lubbe - K. Fischer: Geschichte der Philosophie als Wissenschaft - K. Rosenkranz: Hegel - E. Gans: (Aus:) Vorlesungen uber die Geschichte der letzten funfzig Jahre - F. W. Carove: (Aus:) Ruckblick auf die Ursachen der Franzosischen Revolution - K. Rosenkranz: Kurzer Begriff der offentlichen Meinung - K. Rosenkranz: Uber den Begriff der politischen Partei - H. F. W. Hinrichs: (Aus:) Politische Vorlesungen - K. Rosenkranz: Die Bedeutung der gegenwartigen Revolution und die daraus entspringende Aufgabe der Abgeordneten - (...) K. Rosenkranz: Die organische Gestaltung der Einheit Deutschlands - K. Rosenkranz: Republik und constitutionelle Monarchie - C. L. Michelet: (Aus:) Zur Verfassungsfrage - H. B. Oppenheim: Philosophie des Rechts und der Gesellschaft - H. B. Oppenheim: Uber politische und staatsburgerliche Pflichterfullung - J. E. Erdmann: (Aus:) Philosophische Vorlesungen uber den Staat - C. Rossler: (Aus:) System der Staatslehre. (shrink)

Die analytische Philosophie hat selbst da, wo sie explizit an Kant anschließt, erhebliche Schwierigkeiten mit dessen Idee eines synthetischen Wissens a priori. Damit verliert sie eine ganze Dimension der philosophischen Tradition. Das vorliegende Buch gewinnt diese Idee zurück, indem es gerade den Anschauungsbezug und damit den Zeitbezug des menschlichen Denkens zum Gegenstand einer logischen Untersuchung macht. Nur wenn man die Zeit als inneres und formbildendes Merkmal des menschlichen Aussagens erkennt, versteht man den Begriff empirischer Wahrheit und sinnlich vermittelter Erkenntnis. In (...) diesem Gedanken, so zeigt sich, liegt die Einheit einer philosophischen Tradition, die Aristoteles mit Kant und beide mit dem späten Wittgenstein verbindet. (shrink)

The topic of this book is self-consciousness, which is a kind of knowledge, namely knowledge of oneself as oneself, or self-knowledge.

This section aims to summarize and conclude Part I in the form of a taxonomy of legitimate and illegitimate corporate moral responsibility attributions. I believe we can categorise four types of corporate moral responsibility attributions two of which are legitimate and two which are illegitimate with regard to our concept of moral agency and our moral intuition of fairness.

Modern individuality is the not-so-secret protagonist of Hegel’s practical philosophy.

Recent studies indicate that mammalian chromosomes contain discretecis‐acting loci that control replication timing, mitotic condensation, and stability of entire chromosomes. Disruption of the large non‐coding RNA gene ASAR6 results in late replication, an under‐condensed appearance during mitosis, and structural instability of human chromosome 6. Similarly, disruption of the mouse Xist gene in adult somatic cells results in a late replication and instability phenotype on the X chromosome. ASAR6 shares many characteristics with Xist, including random mono‐allelic expression and asynchronous replication timing. (...) Additional “chromosome engineering” studies indicate that certain chromosome rearrangements affecting many different chromosomes display this abnormal replication and instability phenotype. These observations suggest that all mammalian chromosomes contain “inactivation/stability centers” that control proper replication, condensation, and stability of individual chromosomes. Therefore, mammalian chromosomes contain four types ofcis‐acting elements, origins, telomeres, centromeres, and “inactivation/stability centers”, all functioning to ensure proper replication, condensation, segregation, and stability of individual chromosomes. (shrink)